Publication Name	World Journal of Gastroenterology
Manuscript ID	123426
DOI	10.3748/wjg.123426
Country	Serbia

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Bitter side of sweet: A stage-dependent immunometabolic model linking metabolic syndrome and inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Marina M Jovanovic, Bojana J Simovic Markovic, Nevena M Gajovic, Milan M Jovanovic, Miodrag V Jocic, Bojan S Stojanovic, Irfan F Corovic, Nevena Todorovic, Ivan P Jovanovic and Amedeo Amedei
Funding Agency and Grant Number
Corresponding Author	Ivan P Jovanovic, Professor, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac 34000, Serbia. ivanjovanovic77@gmail.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Metabolic syndrome; Immune dysregulation; Gut microbiota
Core Tip	This review explores the interplay between metabolic syndrome and inflammatory bowel disease through shared pathways and stage-specific immune alterations, presenting a conceptual model of their relationship, highlighting clinical and therapeutic implications, and outlining potentially new directions for future research.
Citation	Jovanovic MM, Simovic Markovic BJ, Gajovic NM, Jovanovic MM, Jocic MV, Stojanovic BS, Corovic IF, Todorovic N, Jovanovic IP, Amedei A. Bitter side of sweet: A stage-dependent immunometabolic model linking metabolic syndrome and inflammatory bowel disease. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123426
PDF	123426-in-press.pdf

Received	2026-05-18 09:35
Peer-Review Started	2026-05-18 09:36
First Decision by Editorial Office Director	2026-06-09 11:21
Return for Revision	2026-06-09 11:21
Revised	2026-06-23 05:18
Publication Fee Transferred	2026-07-21 21:02
Second Decision by Editor	2026-08-31 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-31 08:16
Articles in Press	2026-08-31 08:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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