Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123688
DOI	10.4251/wjgo.123688
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Occult pancreatic ductal adenocarcinoma in patients undergoing invasive evaluation for chronic pancreatitis: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Wan-Zhen Wei, Kong-Yuan Wei, Hai-Rong He, Hao-Ze Leng, Xue Yang, Liang Han, Yi-Na Jiang, Jing Xue, Zheng Wang and Wan-Xing Duan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82372895 National Natural Science Foundation of China 82172853 the Key Research and Development Program of Shaanxi 2024SF2-GJHX-03 the Natural Science Foundation of Shaanxi Province 2023-JC-ZD-54 the Innovative Team Foundation of Shaanxi Health Commission 2024TD-16
Corresponding Author	Wan-Xing Duan, MD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. 15339184808@163.com
Key Words	Pancreatic ductal adenocarcinoma; Chronic pancreatitis; Carbohydrate antigen 19-9; Carcinoembryonic antigen; Serum ionized calcium
Core Tip	Chronic pancreatitis (CP) is a well-established risk factor for pancreatic ductal adenocarcinoma (PDAC), yet distinguishing between the two conditions remains clinically challenging. In this study, 9.2% of 359 patients with CP who underwent invasive procedures were histopathologically diagnosed with occult PDAC. Elevated serum ionized calcium, carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) levels were identified as independent predictors of occult malignancy, with dual markers of CA19-9 and CEA showing particular diagnostic value. Patients with CP are at risk of missed PDAC diagnosis. Our study identified readily available biomarkers to guide the detection of PDAC in this high-risk population.
Citation	Wei WZ, Wei KY, He HR, Leng HZ, Yang X, Han L, Jiang YN, Xue J, Wang Z, Duan WX. Occult pancreatic ductal adenocarcinoma in patients undergoing invasive evaluation for chronic pancreatitis: A retrospective study. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123688
PDF	123688-in-press.pdf

Received	2026-05-27 06:49
Peer-Review Started	2026-05-27 06:49
First Decision by Editorial Office Director
Return for Revision	2026-07-06 07:58
Revised	2026-07-17 03:57
Publication Fee Transferred	2026-08-05 07:42
Second Decision by Editor	2026-08-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:24
Articles in Press	2026-08-28 09:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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