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Articles in Press
9/17/2026 9:28:20 AM | Browse: 11 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Trans-3-indoleacrylic acid ameliorates dextran sulfate sodium-induced colitis by modulating macrophage M1 polarization through the aryl hydrocarbon receptor pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Wei Tuo, Xing Wu, Zhao-Hua Shen and Xiao-Yan Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Hunan Province |
2023JJ40902 |
| Bai Qiuen-Qi Yin Future Multi-Disciplinary Research Capability Construction Project |
BCF-QYWL-XH-2024-5 |
| Beijing Science and Technology Innovation Medical Development Fund Project |
KC2023-ZZ-0011-01 |
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| Corresponding Author |
Xiao-Yan Wang, Chief Physician, PhD, Principal Investigator, Professor, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha 410013, Hunan Province, China. wangxiaoyan@csu.edu.cn |
| Key Words |
Ulcerative colitis; Trans-3-indoleacrylic acid; Macrophage polarization; Aryl hydrocarbon receptor; Gut microbiota; Short-chain fatty acids |
| Core Tip |
Microbiota-derived tryptophan metabolites contribute to intestinal immune homeostasis, but the immunoregulatory role of trans-3-indoleacrylic acid (IDA) in ulcerative colitis (UC) remains unclear. This study demonstrates that IDA alleviates dextran sulfate sodium-induced colitis by suppressing pro-inflammatory M1 macrophage polarization through activation of the aryl hydrocarbon receptor (AHR)-CYP1A1 pathway. IDA treatment is also associated with alterations in gut microbiota composition and short-chain fatty acid profiles. These findings identify the IDA-AHR-macrophage axis as a potential therapeutic target for UC. |
| Citation |
Tuo JW, Wu X, Shen ZH, Wang XY. Trans-3-indoleacrylic acid ameliorates dextran sulfate sodium-induced colitis by modulating macrophage M1 polarization through the aryl hydrocarbon receptor pathway. World J Gastroenterol 2026; In press
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Received |
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2026-05-28 06:24 |
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Peer-Review Started |
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2026-05-28 06:24 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-13 04:02 |
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Revised |
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2026-07-26 22:00 |
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Publication Fee Transferred |
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2026-08-10 15:34 |
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Second Decision by Editor |
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2026-09-17 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-17 09:28 |
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Articles in Press |
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2026-09-17 09:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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