Publication Name	World Journal of Gastroenterology
Manuscript ID	123795
DOI	10.3748/wjg.123795
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction
Manuscript Source	Unsolicited Manuscript
All Author List	Guang-Bo Wu, Gu-Qing Luo, Min Chen, Kua-Wen Cai, Xiao-Tong You, Fu Han, Na-Zhu Zhang, Meng Luo, Qing Li, Hai-Zhong Huo and Qiang Fan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82500736 and No. 81970526 China Postdoctoral Science Foundation General Fund No. 2025M771961 Yunnan Province Science and Technology Plan Project Medical and Health Special Project No. 202603CL100029 Pu’er Municipal Science and Technology Bureau of Yunnan Province, Key Project of the Joint Special Program for Medical Research No. KJXM202509080389
Corresponding Author	Qiang Fan, MD, Department of General Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639 Manufacturing Bureau Road, Shanghai 200011, China. 13472665251@163.com
Key Words	Portal hypertension; Splanchnic hyperdynamic circulation; Melatonin; VEGFR-2; POMK; Liver cirrhosis
Core Tip	This study uncovers a novel protective role for melatonin (MLT) in alleviating splanchnic hyperdynamic circulation in cirrhotic portal hypertension. Using in vivo and in vitro models, we demonstrate that MLT effectively reduces portal pressure by inhibiting pathological mesenteric angiogenesis. Mechanistically, our multi-omics and functional analyses reveal for the first time that MLT exerts its anti-angiogenic effects by specifically disrupting the physical interaction between POMK and VEGFR-2, thereby dampening the VEGF signaling cascade. These findings highlight the POMK-VEGFR-2 axis as a critical pathophysiological driver and propose MLT as a promising, translatable candidate for managing cirrhotic hemodynamic complications.
Citation	Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123795
PDF	123795-in-press.pdf

Received	2026-05-29 07:23
Peer-Review Started	2026-05-29 07:24
First Decision by Editorial Office Director
Return for Revision	2026-07-06 06:46
Revised	2026-07-30 02:05
Publication Fee Transferred	2026-08-27 13:30
Second Decision by Editor	2026-09-24 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-24 08:47
Articles in Press	2026-09-24 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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