Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123838
DOI	10.4251/wjgo.123838
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	CYP2W1 promotes experimental metastatic-colonization phenotypes and is associated with cholesterol-biosynthesis-related molecular alterations in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Zhang, Fu-Li Xin, Feng-Le Jiang, Chang-Hai Li, Chun-Kang Yang and Jian-Min Wang
Funding Agency and Grant Number	Funding Agency Grant Number IIT Funds of Fujian Cancer Hospital 202412003 Scientific Research Foundation of Fujian Cancer Hospital F2328R-RXTD04-01, F2527K-BH01 Fujian Provincial Natural Science Foundation of China 2023J011297, 2024J08274 Joint Funds for the Innovation of Science and Technology, Fujian Province 2023Y9416, 2024Y9605
Corresponding Author	Chun-Kang Yang, Chief Physician, MD, PhD, Department of Gastrointestinal Surgical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou 350014, Fujian Province, China. chunkang129@fjmu.edu.cn
Key Words	Colorectal cancer; Liver metastasis; CYP2W1; Cholesterol metabolism; Protein kinase B; Mechanistic target of rapamycin; SREBF2
Core Tip	This work associates cytochrome P450 family 2 subfamily W member 1 (CYP2W1) with cholesterol-related molecular alterations in metastatic colorectal cancer. CYP2W1 knockdown correlates with reduced phosphorylated protein kinase B/phosphorylated mechanistic target of rapamycin activity, diminished nuclear SREBF2 abundance and lower cholesterol biosynthesis related molecule levels. Exogenous cholesterol supplementation could partially rescue malignant phenotypes after CYP2W1 knockdown. Paired human primary-metastasis tissue exhibited concordant expression patterns. Direct causal validation for this signaling axis remains to be established.
Citation	Zhang H, Xin FL, Jiang FL, Li CH, Yang CK, Wang JM. CYP2W1 promotes experimental metastatic-colonization phenotypes and is associated with cholesterol-biosynthesis-related molecular alterations in colorectal cancer. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123838
PDF	123838-in-press.pdf

Received	2026-06-01 08:00
Peer-Review Started	2026-06-01 08:00
First Decision by Editorial Office Director
Return for Revision	2026-07-02 06:15
Revised	2026-08-27 07:13
Publication Fee Transferred	2026-09-20 08:10
Second Decision by Editor	2026-11-12 06:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-12 09:52
Articles in Press	2026-11-12 09:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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