Publication Name	World Journal of Gastroenterology
Manuscript ID	123870
DOI	10.3748/wjg.123870
Country	China

Category	Oncology
Manuscript Type	Correspondence
Article Title	Letter to the editor: Serum S100A6 as complementary biomarker for pancreatic cancer-an advance needing clearer delineation
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Xiao Ni and Jia-Ju Xu
Funding Agency and Grant Number
Corresponding Author	Jia-Ju Xu, MD, Department of Medical Oncology, Tai’an City Central Hospital, No. 29 Longtan Road, Tai’an 271000, Shandong Province, China. jiajuxu1101@163.com
Key Words	S100A6; Pancreatic cancer; Early detection; CA19-9; Complementary biomarker; Chronic pancreatitis; Lewis antigen; External validation; Decision curve analysis
Core Tip	This letter commends the innovative study by Bae et al as the first large prospective study evaluating serum S100A6 for early detection of pancreatic cancer, and outlines five points requiring attention. The “early-stage” group consists predominantly of stage II; absence of Lewis antigen status information limits mechanistic understanding of S100A6’s complementary role; single center design and use of historical samples limit generalizability; absence of decision curve analysis means net benefit is unassessed; and how S100A6 enters the circulation is unidentified. Overall, serum S100A6 is promising, but these limitations must be addressed before clinical implementation.
Citation	Ni CX, Xu JJ. Letter to the editor: Serum S100A6 as complementary biomarker for pancreatic cancer-an advance needing clearer delineation. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123870
PDF	123870-in-press.pdf

Received	2026-06-01 08:08
Peer-Review Started	2026-06-01 08:08
First Decision by Editorial Office Director	2026-06-15 07:35
Return for Revision	2026-06-15 07:35
Revised	2026-06-15 11:47
Publication Fee Transferred
Second Decision by Editor	2026-08-07 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 10:21
Articles in Press	2026-08-10 10:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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