Publication Name	World Journal of Hepatology
Manuscript ID	123924
DOI	10.4254/wjh.123924
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Radiologic partial response poorly predicts pathologic complete response in hepatocellular carcinoma after conversion therapy
Manuscript Source	Invited Manuscript
All Author List	Chi Xu, Qiong-Yu Liang, Jia-Peng Sun, Kang Zhou, Jie Pan and Hai-Tao Zhao
Funding Agency and Grant Number
Corresponding Author	Jie Pan, MD, PhD, Department of Radiology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China. markpan6885@163.com
Key Words	Hepatocellular carcinoma; Conversion therapy; Pathologic complete response; Radiologic-pathologic correlation; Surgical resection
Core Tip	Radiologic response is widely used to assess treatment efficacy in hepatocellular carcinoma after conversion therapy, yet its correlation with pathological response remains uncertain. In this study, radiologic partial response assessed by both Response Evaluation Criteria in Solid Tumours (RECIST) version 1.1 and modified RECIST showed poor concordance with pathologic complete response (pCR). Although all patients achieving pCR were classified as responders by modified RECIST, most radiologic responders still had residual viable tumor. These findings underscore the limitations of imaging-based response assessment and support the integration of additional biomarkers to improve preoperative evaluation and treatment planning.
Citation	Xu C, Liang QY, Sun JP, Zhou K, Pan J, Zhao HT. Radiologic partial response poorly predicts pathologic complete response in hepatocellular carcinoma after conversion therapy. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.123924
PDF	123924-in-press.pdf

Received	2026-06-02 07:36
Peer-Review Started	2026-06-02 07:37
First Decision by Editorial Office Director
Return for Revision	2026-07-07 03:15
Revised	2026-07-17 07:36
Publication Fee Transferred
Second Decision by Editor	2026-08-28 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:25
Articles in Press	2026-08-28 09:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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