Publication Name	World Journal of Stem Cells
Manuscript ID	123933
DOI	10.4252/wjsc.123933
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Experimental study on ultrasound-targeted microbubble destruction promoting the proliferation, migration of human umbilical cord mesenchymal stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Pan Zhang, Bo-Ya La, Man-Li Zhang, Burleshan Rewan, Ling-Yun Zhang and Xiao-Lin La
Funding Agency and Grant Number	Funding Agency Grant Number Health Science and Technology Plan Project of the Autonomous Region - Innovative Research Project 2025001CXKMYM650030870 Open Project of the State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia SKL-HIDCA-2024-GX2 Tianshan Talents Leading Talent Project for Medicine and Health Care TSYC202401A023
Corresponding Author	Xiao-Lin La, Reproductive Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, No. 137 South Liyushan Road, Xinshi District, Urumqi 830054, Xinjiang Uygur Autonomous Region, China. 909232905@qq.com
Key Words	Human umbilical cord mesenchymal stem cells; Ultrasound-targeted microbubble destruction technology; Migration; C-X-C chemokine receptor type 4; Microbubbles
Core Tip	Enhancing the migratory capacity of transplanted human umbilical cord mesenchymal stem cells (hUCMSCs) remains a critical challenge in regenerative medicine. Ultrasound-targeted microbubble destruction (UTMD) is a promising non-invasive physical intervention, yet its optimal parameters and underlying mechanisms for promoting hUCMSC migration require further elucidation. Here, we introduce that when the microbubbles concentration is 1 × 107 particles/mL and the ultrasound exposure time is 300 seconds, UTMD technology can promote cell proliferation, migration by upregulating the expression levels of the C-X-C chemokine receptor type 4 gene and protein in hUCMSCs.
Citation	Zhang P, La BY, Zhang ML, Rewan B, Zhang LY, La XL. Experimental study on ultrasound-targeted microbubble destruction promoting the proliferation, migration of human umbilical cord mesenchymal stem cells. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.123933
PDF	123933-in-press.pdf

Received	2026-06-03 07:34
Peer-Review Started	2026-06-03 07:34
First Decision by Editorial Office Director
Return for Revision	2026-06-29 02:14
Revised	2026-07-12 20:20
Publication Fee Transferred	2026-07-30 07:09
Second Decision by Editor	2026-08-20 02:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-16 09:36
Articles in Press	2026-09-16 09:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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