Publication Name	World Journal of Gastroenterology
Manuscript ID	123982
DOI	10.3748/wjg.123982
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Autonomic nervous system as a key modulator in stress-related inflammatory bowel disease: Mechanisms and therapeutic implications
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Xin Hu, Xue-Ping Zhang, Cheng-Xiang Wang, Rui-Rong Yang, Li-Xin Ma, Suo-Wei Wu, Wen-Qi Jiang, Pu-Min Deng, Tao Zhang, Xiao-Lan Su and Wei Wei
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Pharmaceutical and Health Collaborative High-Quality R&D Project on Traditional Chinese Medicine zyygzl-2026-004 National Pilot Project for Integrated Chinese and Western Medicine in the Management of Severe and Refractory Diseases: Ulcerative Colitis (Chronic Dysentery), and the Specialized Research Program for Self-Proposed Projects at Wangjing Hospital, China Academy of Chinese Medical Sciences WJYY-ZZXT-2025-35
Corresponding Author	Wei Wei, Chief Physician, MD, Principal Investigator, Professor, Department of Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 South Middle Ring Road, Wangjing, Chaoyang District, Beijing 100102, China. sxxtyy@sina.com
Key Words	Autonomic nervous system; Brain-gut axis; Stress; Inflammatory bowel disease; Mechanism; Therapy
Core Tip	This review provides a novel perspective on stress-associated inflammatory bowel disease by highlighting autonomic nervous system dysregulation as a key link between psychological stress and intestinal inflammation. We discuss the dual roles of sympathetic and vagal pathways, disease-specific autonomic responses in ulcerative colitis and Crohn’s disease, and emerging autonomic nervous system-targeted therapies. Current controversies and future directions toward personalized neuromodulation are also addressed.
Citation	Hu XX, Zhang XP, Wang CX, Yang RR, Ma LX, Wu SW, Jiang WQ, Deng PM, Zhang T, Su XL, Wei W. Autonomic nervous system as a key modulator in stress-related inflammatory bowel disease: Mechanisms and therapeutic implications. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123982
PDF	123982-in-press.pdf

Received	2026-06-03 06:46
Peer-Review Started	2026-06-03 06:46
First Decision by Editorial Office Director
Return for Revision	2026-07-16 03:19
Revised	2026-07-29 01:30
Publication Fee Transferred	2026-08-06 08:53
Second Decision by Editor	2026-09-16 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-16 09:37
Articles in Press	2026-09-16 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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