Publication Name	World Journal of Diabetes
Manuscript ID	124007
DOI	10.4239/wjd.124007
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Jiao-Tai-Wan improves pancreatic β cell function by regulating ferroptosis via the Nrf2/NQO1 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Jing Zhao, Yu Chen, Qi-Feng Wang, Ying-Ying Fu, Kun Wang, Yu Yang, Wen Cao and Chao Liu
Funding Agency and Grant Number	Funding Agency Grant Number the Medical Research Project of Jiangsu Provincial Health Commission M2021111 Traditional Chinese Medicine Science and Technology Project of Jiangsu Province MS2024029
Corresponding Author	Chao Liu, PhD, Professor, Department of Endocrinology, Affiliated Hospital of integrated traditional Chinese and Western medicine, Nanjing University of Traditional Chinese Medicine, jiangsu nanjing hongshan road 100, Nanjing 210000, Jiangsu Province, China. liuchao@jsatcm.com
Key Words	Jiao-Tai-Wan; Ferroptosis; Nrf2/NQO1 signaling pathway; Pancreatic β cell function; Network pharmacology
Core Tip	Jiao-Tai-Wan (JTW) is a traditional Chinese herbal formula used for treating hyperglycemia, yet its underlying mechanism remains incompletely understood. This study integrated network pharmacology, weighted gene coexpression network analysis, and in vivo and in vitro experiments to investigate whether JTW protects pancreatic β cell function through ferroptosis inhibition. We identified NQO1 as a core target and demonstrated that JTW regulates ferroptosis by activating the Nrf2/NQO1 signaling pathway to improve pancreatic β cell function. These findings reveal a novel antiferroptotic mechanism contributing to the hypoglycemic action of JTW.
Citation	Zhao YJ, Chen Y, Wang QF, Fu YY, Wang K, Yang Y, Cao W, Liu C. Jiao-Tai-Wan improves pancreatic β cell function by regulating ferroptosis via the Nrf2/NQO1 signaling pathway. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.124007
PDF	124007-in-press.pdf

Received	2026-06-04 00:47
Peer-Review Started	2026-06-05 09:43
First Decision by Editorial Office Director
Return for Revision	2026-06-23 06:13
Revised	2026-07-31 14:09
Publication Fee Transferred	2026-08-27 13:56
Second Decision by Editor	2026-10-09 09:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:08
Articles in Press	2026-10-28 10:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com