Publication Name	World Journal of Gastroenterology
Manuscript ID	124080
DOI	10.3748/wjg.124080
Country	Türkiye

Category	Transplantation
Manuscript Type	Review
Article Title	Liver transplantation for intrahepatic cholangiocarcinoma: From contraindication to biology-driven selection
Manuscript Source	Unsolicited Manuscript
All Author List	Sami Akbulut and Sezai Yilmaz
Funding Agency and Grant Number
Corresponding Author	Sami Akbulut, FACS, MD, PhD, Professor, Department of Surgery and Liver Transplantation, Inonu University Faculty of Medicine, Elazig Yolu 10 Kilometers, Malatya 44280, Türkiye. akbulutsami@gmail.com
Key Words	Intrahepatic cholangiocarcinoma; Liver transplantation; Transplant oncology; Patient selection; Neoadjuvant therapy; Tumor biology; Recurrence
Core Tip	Liver transplantation (LT) should not be regarded as a routine treatment for intrahepatic cholangiocarcinoma, but as a highly selective option for carefully chosen patients. The most established evidence concerns cirrhotic patients with very early solitary tumors, whereas LT for selected patients with unresectable, liver-limited disease controlled after neoadjuvant therapy remains promising but investigational. In both settings, appropriate candidate selection requires durable disease stability, accurate staging, histological confirmation when feasible, and reliable exclusion of nodal and extrahepatic spread. Multidisciplinary assessment is essential, and LT should be considered only within strict selection protocols rather than as an alternative to resection in patients with safely resectable disease.
Citation	Akbulut S, Yilmaz S. Liver transplantation for intrahepatic cholangiocarcinoma: From contraindication to biology-driven selection. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124080
PDF	124080-in-press.pdf

Received	2026-06-05 02:35
Peer-Review Started	2026-06-05 02:35
First Decision by Editorial Office Director
Return for Revision	2026-06-22 06:30
Revised	2026-07-12 11:33
Publication Fee Transferred	2026-08-13 21:19
Second Decision by Editor	2026-08-20 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-20 08:47
Articles in Press	2026-08-20 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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