Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124110
DOI	10.4251/wjgo.124110
Country	China

Category	Surgery
Manuscript Type	Basic Study
Article Title	Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling
Manuscript Source	Unsolicited Manuscript
All Author List	Qian-Cheng Du, Yu Bai, De-Hua Zhou, Hua Yu and Hui Nian
Funding Agency and Grant Number
Corresponding Author	Hui Nian, MD, Department of Thoracic Surgery, Shanghai Xuhui Central Hospital, No. 366 Longchuan North Road, Xuhui District, Shanghai 200031, China. hnian14@fudan.edu.cn
Key Words	Fatty acid desaturase 1; Esophageal cancer; Ferroptosis; Phospholipid metabolism; Lipid raft
Core Tip	Esophageal cancer patients have a poor prognosis with unclear immunometabolic mechanisms. Fatty acid desaturase 1 (FADS1), a key lipid metabolism enzyme, is linked to multiple cancers, but its role in esophageal cancer immunity is unknown. In this study, FADS1, which is overexpressed in tumor-infiltrating M1 macrophages, was identified as a causal factor for esophageal cancer. Mechanistically, FADS1 accumulates 1-palmitoyl-2-stearoyl-glycerophosphocholine, promotes lipid raft assembly, and triggers ferroptosis in M1 macrophages, impairing their antitumor function. Inhibiting FADS1 expression suppressed ferroptosis and restored M1 macrophage activity. The FADS1 inhibitor BRD-K95779464 was identified by artificial intelligence screening. This work reveals a novel FADS1-mediated immunometabolic pathway in esophageal cancer.
Citation	Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124110
PDF	124110-in-press.pdf

Received	2026-06-08 06:08
Peer-Review Started	2026-06-08 06:09
First Decision by Editorial Office Director
Return for Revision	2026-07-06 06:56
Revised	2026-07-14 12:12
Publication Fee Transferred	2026-07-31 14:29
Second Decision by Editor	2026-08-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:29
Articles in Press	2026-08-28 09:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com