Publication Name	World Journal of Cardiology
Manuscript ID	124181
DOI	10.4330/wjc.124181
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Xin-II shows cardioprotective effects in a rat model of chronic heart failure: An integrated network pharmacology and transcriptomic
Manuscript Source	Unsolicited Manuscript
All Author List	Xi-Ju Liu, Yan Cong, Ran Zheng, Ming Li, Zhi Xiu, Peng-Fei Hu, Guo-Hua Wu, Cha-Gan Lianhua and Quan Wan
Funding Agency and Grant Number	Funding Agency Grant Number The Youth Research Start-up Fund of the Affiliated Hospital of Inner Mongolia University for Nationalities No. 2020QNJJ02
Corresponding Author	Quan Wan, Associate Chief Physician, PhD, Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia Minzu University, No. 1742 East Section of Huolinghe Street, TongLiao 028000, Inner Mongolia Autonomous Region, China. wanquan120@126.com
Key Words	Chronic heart failure; Xin-II; Mongolian medicine; Peroxisome proliferator-activated receptor/hypoxia-inducible factor-1 alpha signaling pathway; Mechanism
Core Tip	This study integrates network pharmacology and RNA-seq to reveal that Mongolian Medicine Xin-II alleviates chronic heart failure by modulating the peroxisome proliferator-activated receptor/hypoxia-inducible factor-1 signaling pathway, improving cardiac function and myocardial pathology.
Citation	Liu XJ, Cong Y, Zheng R, Li M, Xiu Z, Hu PF, Wu GH, Lianhua CG, Wan Q. Xin-II shows cardioprotective effects in a rat model of chronic heart failure: An integrated network pharmacology and transcriptomic. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.124181
PDF	124181-in-press.pdf

Received	2026-06-09 08:16
Peer-Review Started	2026-06-09 08:16
First Decision by Editorial Office Director
Return for Revision	2026-07-23 07:55
Revised	2026-08-13 13:44
Publication Fee Transferred	2026-09-28 12:18
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 02:40
Articles in Press	2026-11-02 02:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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