Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	124240
DOI	10.4240/wjgs.124240
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Meta-analysis of short-term and long-term outcomes of laparoscopic vs open hepatectomy for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Sheng-He Li
Funding Agency and Grant Number
Corresponding Author	Sheng-He Li, The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Avenue Middle, Haizhu District, Guangzhou 510282, Guangdong Province, China. 13566397747@163.com
Key Words	Hepatocellular carcinoma; Laparoscopic hepatectomy; Open hepatectomy; Overall survival; Progression-free survival; Postoperative complications; Meta-analysis
Core Tip	This is a meta-analysis of 10 randomized controlled trials from around the world comparing laparoscopic vs open hepatectomy for hepatocellular carcinoma (HCC) in 587 patients with indications. The cumulative incidence of complications at 1 month after surgery was significantly lower (odds ratio = 0.52, P < 0.01) in the laparoscopic hepatectomy (LH) group, confirming clear short-term benefits in terms of postoperative morbidity with this approach. While patients with LH suffered lower 5-year overall survival than their counterparts after adjustment (hazard ratios = 1.34, P < 0.01) and borderline inferior progression-free survival (P = 0.04). Three-month rates of recurrence were not significantly different across approaches. These findings exemplify the clinical dilemma: LH is associated with short-term safety benefits, which should be carefully balanced against long-term oncological compromise when choosing surgical approach for HCC in our patient cohort.
Citation	Li SH. Meta-analysis of short-term and long-term outcomes of laparoscopic vs open hepatectomy for hepatocellular carcinoma. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.124240
PDF	124240-in-press.pdf

Received	2026-06-23 10:22
Peer-Review Started	2026-06-23 10:22
First Decision by Editorial Office Director
Return for Revision	2026-07-15 07:40
Revised	2026-08-10 08:19
Publication Fee Transferred	2026-10-05 03:18
Second Decision by Editor	2026-11-06 06:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-06 10:30
Articles in Press	2026-11-06 10:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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