Publication Name	World Journal of Gastroenterology
Manuscript ID	124251
DOI	10.3748/wjg.124251
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gan-tang-yi decoction attenuates endoplasmic reticulum stress in cirrhotic rats and CCl4-induced BRL-3A cells by regulating PERK/ATF4/CHOP pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Fang Xiong, Na Jiang, Yi-Fan Zhang, Ying He, Dong-Ya Chen, Yi-Hui Liu, Shu-Yan Zhang, Gao-Feng Chen, Chang-Qing Zhao and Hong Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82074100 Hangzhou Medical Health Technology Project ZD20230032 Scientific Research Fund for Traditional Chinese Medicine in Zhejiang Province 2023ZL551, 2024ZR088
Corresponding Author	Hong Xu, Chief Physician, Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, No. 208 Huancheng Dong Road, Hangzhou 310003, Zhejiang Province, China. hongxuhzrc@aliyun.com
Key Words	Gan-tang-yi decoction; Cirrhosis; Endoplasmic reticulum stress; Protein kinase RNA-like endoplasmic reticulum kinase; C/EBP homologous protein
Core Tip	Gan-tang-yi decoction (GTYD) alleviates liver injury, fibrosis, and insulin resistance in cirrhotic rats by suppressing endoplasmic reticulum stress. GTYD inhibits the pro-apoptotic PERK/ATF4/CHOP signaling pathway both in vivo and in vitro. Activation of PERK by CCT020312 reverses the hepatoprotective effects of GTYD, confirming its pathway specificity. GTYD reduces carbon tetrachloride-induced hepatocyte apoptosis by attenuating endoplasmic reticulum stress, as validated by the effects of 4-phenyl butyrate and thapsigargin.
Citation	Xiong JF, Jiang N, Zhang YF, He Y, Chen DY, Liu YH, Zhang SY, Chen GF, Zhao CQ, Xu H. Gan-tang-yi decoction attenuates endoplasmic reticulum stress in cirrhotic rats and CCl4-induced BRL-3A cells by regulating the PERK/ATF4/CHOP pathway. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124251
PDF	124251-in-press.pdf

Received	2026-06-10 08:36
Peer-Review Started	2026-06-10 08:36
First Decision by Editorial Office Director
Return for Revision	2026-07-06 10:30
Revised	2026-07-29 07:48
Publication Fee Transferred	2026-08-10 00:42
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:23
Articles in Press	2026-11-04 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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