Publication Name	World Journal of Hepatology
Manuscript ID	124302
DOI	10.4254/wjh.124302
Country	Jordan

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Nanostructured propolis attenuates experimental liver fibrosis and is associated with changes in LC3 and p62 expression
Manuscript Source	Unsolicited Manuscript
All Author List	Samar Ramadan Mohammed, Ahmed El-Sayed Nour El Deen, Wael M Elsaed, Eman E Elwakeel, Amiran Osman, Eman S El-Ashry, Rania N Sherif, Kamal G Botros, Sally Abdallah Mostafa and Dina Abdalla Arida
Funding Agency and Grant Number	Funding Agency Grant Number the Deanship of Scientific Research at Zarqa University
Corresponding Author	Ahmed El-Sayed Nour El Deen, Professor, Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, -, Zarqa 13110, Jordan. a.nourelden@zu.edu.jo
Key Words	Liver fibrosis; Propolis nanoparticles; Autophagy; Carbon tetrachloride; Oxidative stress
Core Tip	This study demonstrates that nanostructured propolis exerts greater antifibrotic effects than conventional propolis in a carbon tetrachloride-induced rat model of liver fibrosis. Propolis nanoparticles significantly reduced liver injury, oxidative stress, and collagen deposition while partially reversing alterations in the autophagy-related markers microtubule-associated protein 1 light chain 3 and sequestosome 1. These findings suggest that nanostructuring enhances the biological activity of propolis and support its potential as a promising strategy for improving antifibrotic therapy.
Citation	Mohammed SR, Nour El Deen AES, Elsaed WM, Elwakeel EE, Osman A, El-Ashry ES, Sherif RN, Botros KG, Mostafa SA, Arida DA. Nanostructured propolis attenuates experimental liver fibrosis and is associated with changes in LC3 and p62 expression. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124302
PDF	124302-in-press.pdf

Received	2026-06-12 03:46
Peer-Review Started	2026-06-12 03:46
First Decision by Editorial Office Director
Return for Revision	2026-06-23 01:07
Revised	2026-07-03 21:26
Publication Fee Transferred	2026-09-17 08:39
Second Decision by Editor	2026-10-22 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-22 09:16
Articles in Press	2026-10-22 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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