Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	124347
DOI	10.4240/wjgs.124347
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Association between pathological tumor regression and initial recurrence patterns after neoadjuvant chemotherapy for gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Fei-Yu Meng, Zheng-Hao Hao, Rui Deng, Ming-Zhi Cai, Ru-Peng Zhang, Ji-Long Yang and Jing-Yu Deng
Funding Agency and Grant Number	Funding Agency Grant Number Scientific and Noncommunicable Chronic Diseases National Science and Technology Major Project No. 2023ZD0501504
Corresponding Author	Jing-Yu Deng, MD, PhD, Professor, Department of Gastric Surgery, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy; Tianjin Key Laboratory of Digestive Cancer; Tianjin’s Clinical Research Center for Cancer, Huanhu West Road, Tianjin 300060, China. dengery@126.com
Key Words	Stomach neoplasms; Neoadjuvant therapy; Adjuvant chemotherapy; Recurrence; Tumor regression grade; Gastrectomy; Prognosis; Recurrence patterns
Core Tip	In 427 patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy and radical gastrectomy, tumor regression grade (TRG) independently predicted recurrence-free survival and was associated with recurrence timing and pattern. Peritoneal recurrence was most common and had the poorest outcomes. TRG 2-3 was linked to earlier locoregional/peritoneal relapse, whereas distant recurrence was relatively more frequent in TRG 0-1, supporting postoperative risk stratification.
Citation	Meng FY, Hao ZH, Deng R, Cai MZ, Zhang RP, Yang JL, Deng JY. Association between pathological tumor regression and initial recurrence patterns after neoadjuvant chemotherapy for gastric cancer. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.124347
PDF	124347-in-press.pdf

Received	2026-06-12 07:40
Peer-Review Started	2026-06-12 07:40
First Decision by Editorial Office Director
Return for Revision	2026-07-15 07:36
Revised	2026-07-28 23:03
Publication Fee Transferred	2026-08-12 07:38
Second Decision by Editor	2026-09-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-09 10:22
Articles in Press	2026-09-09 10:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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