Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	124355
DOI	10.4253/wjge.124355
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Beyond current therapies - any more promising strategies for refractory non-esophageal eosinophilic gastrointestinal diseases?
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Wei, Bo-Tong Ma, Ying-Qian Wang, Li-Xuan Sang and Bing Chang
Funding Agency and Grant Number
Corresponding Author	Bing Chang, Chief Physician, MD, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cb000216@163.com
Key Words	Non EOE eosinophilic gastrointestinal diseases; Endoscopic ultrasound; Fecal microbiota transplantation; Leukapheresis; Eosinophilic gastrointestinal diseases
Core Tip	This letter comments on a multicenter study of non-esophageal eosinophilic gastrointestinal diseases. High relapse rates after initial response to conventional therapies highlight the need for improved treatment strategies. We suggest the use of endoscopic ultrasound in selected patients with suspected deeper-layer involvement or atypical presentations. Additionally, fecal microbiota transplantation and leukapheresis are suggested as exploratory approaches that warrant further investigation. Given that current evidence is limited to case reports and indirect disease models, additional mechanistic and preclinical studies are urgently needed to evaluate their efficacy and safety and formulate optimal individualized regimens for this disease.
Citation	Wei H, Ma BT, Wang YQ, Sang LX, Chang B. Letter to the Editor: Beyond current therapies - any more promising strategies for refractory non-esophageal eosinophilic gastrointestinal diseases? World J Gastrointest Endosc 2026; In press DOI: https://doi.org/10.4253/wjge.124355
PDF	124355-in-press.pdf

Received	2026-06-12 07:35
Peer-Review Started	2026-06-12 07:36
First Decision by Editorial Office Director
Return for Revision	2026-07-15 05:58
Revised	2026-07-28 15:01
Publication Fee Transferred
Second Decision by Editor	2026-08-12 05:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-14 10:04
Articles in Press	2026-08-14 10:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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