Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124375
DOI	10.4251/wjgo.124375
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Transcriptomic analysis and experimental verification reveal the multiple roles of angiogenesis factors in esophageal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ling Xu, Da Li, Tian Xu, Kun Zhang, Jing-Yao Feng, Li-Jun Hu and Jian-Lin Wang
Funding Agency and Grant Number	Funding Agency Grant Number Top Talent of Changzhou “The 14th Five-Year Plan” High-Level Health Talents Training Project 2022CZBJ070 Science and Technology Project of Changzhou Health Commission ZD202313 Clinical Program of Changzhou Medical Center, Nanjing Medical University CMCC202401 Changzhou Sci&Tech Program CJ20253095 Changzhou University-Changzhou Second People’s Hospital Nursing Special Research Project CDHL202503
Corresponding Author	Jian-Lin Wang, Chief Physician, Department of Radiotherapy, The Third Affiliated Hospital of Nanjing Medical University, The Second People’s Hospital of Changzhou, No. 468 Yanling Middle Road, Tianning District, Changzhou 213003, Jiangsu Province, China. wangjianlin@njmu.edu.cn
Key Words	Esophageal cancer; Angiogenesis factor; Prognostic risk model; Independent prognosis factor; APLN
Core Tip	This study highlights that angiogenesis factor-based model could be used as a promising variable for predicting the prognosis of esophageal cancer. When combined with experimental validation, our findings demonstrate the critical role of APLN in the development of esophageal cancer. They also offer a new theoretical and practical framework for classifying tumours functionally and developing personalized treatment strategies.
Citation	Xu L, Li D, Xu T, Zhang K, Feng JY, Hu LJ, Wang JL. Transcriptomic analysis and experimental verification reveal the multiple roles of angiogenesis factors in esophageal cancer. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124375
PDF	124375-in-press.pdf

Received	2026-06-15 08:34
Peer-Review Started	2026-06-15 08:34
First Decision by Editorial Office Director
Return for Revision	2026-07-06 09:07
Revised	2026-07-13 11:52
Publication Fee Transferred	2026-07-30 02:52
Second Decision by Editor	2026-09-08 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-08 09:54
Articles in Press	2026-09-08 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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