Publication Name	World Journal of Gastroenterology
Manuscript ID	124434
DOI	10.3748/wjg.124434
Country	China

Category	Surgery
Manuscript Type	Case Report
Article Title	Endoscopic closure of a giant iatrogenic sigmoid perforation using through-the-scope clips and a nylon loop: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xu Zeng, Fu-Rao Gong, Quan Li, Yong-Bo Shi and Feng Lin
Funding Agency and Grant Number
Corresponding Author	Xu Zeng, Department of Colorectal Surgery, Zigong Hospital of Traditional Chinese Medicine, No. 1000 Longhui Avenue, Ziliujing District, Zigong 643000, Sichuan Province, China. zengxu454527344@163.com
Key Words	Endoscopic closure; Iatrogenic sigmoid perforation; Through-the-scope clip; Nylon loop; Colonoscopy; Case report
Core Tip	Iatrogenic colonic perforations are rare, particularly those involving giant defects. For iatrogenic colonic perforations > 3 cm, surgical intervention is typically prioritized because attempting endoscopic closure entails substantial risks and technical challenges, and reported successes of this approach remain exceedingly scarce. We report the successful use of a single-channel therapeutic colonoscope using through-the-scope clips and a nylon loop for the endoscopic closure of a giant iatrogenic sigmoid perforation (5 cm × 4 cm), an approach that may serve as a clinical reference for endoscopists.
Citation	Zeng X, Gong FR, Li Q, Shi YB, Lin F. Endoscopic closure of a giant iatrogenic sigmoid perforation using through-the-scope clips and a nylon loop: A case report. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124434
PDF	124434-in-press.pdf

Received	2026-06-16 08:22
Peer-Review Started	2026-06-16 08:22
First Decision by Editorial Office Director
Return for Revision	2026-07-30 04:07
Revised	2026-08-07 21:50
Publication Fee Transferred	2026-08-16 02:59
Second Decision by Editor	2026-09-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-10 09:29
Articles in Press	2026-09-10 09:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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