Publication Name	World Journal of Clinical Oncology
Manuscript ID	124498
Country	China

Category	Immunology
Manuscript Type	Minireviews
Article Title	Recent advances on regulatory roles of HuD and promoter hypermethylation for miR-204 in lung cancer development
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Ling Zhang, Jia-Yi Zhu, Jian-Lan Yang, Lai-Ling Du, Wei-Ke Tian, Jian-Guo Zhang and Xiao-Ping Li
Funding Agency and Grant Number	Funding Agency Grant Number General Scientific Research Project of Zhejiang Provincial Department of Education Y202147513
Corresponding Author	Xiao-Ping Li, Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Zhejiang Shuren University, 8 Shuren Street, Hangzhou, Zhejiang Province, 310015, P.R. China, Hangzhou 310015, Zhejiang Province, China. li-xp@zjsru.edu.cn
Key Words	miR-204; HuD; Promoter methylation; Lung cancer; NUAK1; PFN2
Core Tip	miR-204 is a pivotal tumor suppressor in lung cancer, with its inactivation driven by distinct mechanisms across subtypes: In small cell lung cancer, the RNA-binding protein HuD stabilizes oncogenic long non-coding RNAs LYPLAL1-DT and PFN2 mRNA, sequestering miR-204-5p to derepress PFN2 and promote cytoskeletal remodeling and metastasis via a self-amplifying positive feedback loop. In non-small cell lung cancer, promoter hypermethylation mediated by DNA methyltransferase directly silences miR-204 transcription, derepressing NUAK1 to activate mTOR signaling and drive cancer progression. Though operating through discrete upstream pathways and targeting different downstream effectors, the both pathways converge on loss of miR-204 function to foster malignancy. This dual-track regulatory network may provide a basis for subtype-specific molecular typing, prognostic prediction, and targeted intervention strategies, offering new insights for precision therapy of lung cancer.
Citation	Zhang XL, Zhu JY, Yang JL, Du LL, Tian WK, Zhang JG, Li XP. Recent advances on regulatory roles of HuD and promoter hypermethylation for miR-204 in lung cancer development. World J Clin Oncol 2026; In press

Received	2026-06-23 07:14
Peer-Review Started	2026-06-23 07:14
First Decision by Editorial Office Director
Return for Revision	2026-08-03 09:24
Revised	2026-08-10 13:59
Publication Fee Transferred	2026-09-14 12:22
Second Decision by Editor	2026-09-21 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-21 09:46
Articles in Press	2026-09-21 09:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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