Publication Name	World Journal of Translational Medicine
Manuscript ID	124499
DOI	10.5528/wjtm.124499
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Extracellular DNA-associated inflammation in colorectal cancer metastasis: A testable TLR9-NF-κB-SPHK1/S1P framework and translational research agenda
Manuscript Source	Invited Manuscript
All Author List	Yu-Hui Shang, Shuang Han, Kai-Zhen Xu, Wen-Jian Hu, Jiu-Ning Huang and Yan-Dong Miao
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Province Medical and Health Science and Technology Development Plan Project 202203030713, 202503110210, 202509030205 Shandong Traditional Chinese Medicine Science and Technology Program M20254102 Yantai Science and Technology Program 2024YD010 Science and Technology Program of Yantai affiliated Hospital of Binzhou Medical University YTFY2022KYQD06 Twenty-First Century Public Welfare Foundation Academic Research Project JJH2025001
Corresponding Author	Yan-Dong Miao, Cancer Center, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, The 2nd Medical College of Shandong Medical and Pharmaceutical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China. miaoyd_22@ sdmpu.edu.cn
Key Words	Colorectal cancer; Liver metastasis; Extracellular DNA; Neutrophil extracellular traps; Toll-like receptor 9; Nuclear factor-κB; Sphingosine kinase 1/sphingosine-1-phosphate; DNA sensing; Tumor microenvironment; Biomarker development
Core Tip	Extracellular DNA may connect chronic intestinal inflammation to colorectal cancer (CRC) metastasis through multiple DNA sensors and sphingolipid signaling, but the complete Toll-like receptor 9-nuclear factor-κB-sphingosine kinase 1/sphingosine-1-phosphate cascade has not been validated in CRC. This review presents a testable, compartment-aware framework and prioritizes CRC-specific causal studies and staged biomarker validation.
Citation	Shang YH, Han S, Xu KZ, Hu WJ, Huang JN, Miao YD. Extracellular DNA-associated inflammation in colorectal cancer metastasis: A testable TLR9-NF-κB-SPHK1/S1P framework and translational research agenda. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.124499
PDF	124499-in-press.pdf

Received	2026-06-18 02:10
Peer-Review Started	2026-06-18 02:10
First Decision by Editorial Office Director
Return for Revision	2026-07-18 09:02
Revised	2026-09-16 15:05
Publication Fee Transferred
Second Decision by Editor	2026-11-13 03:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-13 10:22
Articles in Press	2026-11-13 10:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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