Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124550
DOI	10.4251/wjgo.124550
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Size-dependent transcriptomic heterogeneity and microbial dysbiosis in Peutz-Jeghers syndrome colorectal polyps: An exploratory self-controlled multi-omics analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Xue Chen, Qian-Wen Ge, Xiang-Yu Li, Wei-Jie Dai and Hong-Gang Wang
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Provincial Medical Key Discipline Cultivation Unit JSDW202233
Corresponding Author	Hong-Gang Wang, Department of Gastroenterology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, No. 1 West Huanghe Road, Huaiyin District, Huaian 223300, Jiangsu Province, China. jgzwhg@njmu.edu.cn
Key Words	Peutz-Jeghers syndrome; Colorectal polyp; Transcriptome; Gut microbiota; Multi-omics
Core Tip	Although colorectal polyps in patients with Peutz-Jeghers syndrome are classically regarded as hamartomas, their malignant potential increases with size. Using a self-controlled, multi-omics design to analyze polyps from a single patient, we provide preliminary evidence that small and medium polyps are chiefly metabolic. However, large polyps display widespread transcriptional downregulation coupled with selective enrichment of the nuclear factor kappa B and B-cell receptor pathways, accompanied by distinct microbial dysbiosis. These exploratory findings offer molecular insight for future investigations.
Citation	Chen MX, Ge QW, Li XY, Dai WJ, Wang HG. Size-dependent transcriptomic heterogeneity and microbial dysbiosis in Peutz-Jeghers syndrome colorectal polyps: An exploratory self-controlled multi-omics analysis. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124550
PDF	124550-in-press.pdf

Received	2026-06-18 06:30
Peer-Review Started	2026-06-18 06:31
First Decision by Editorial Office Director
Return for Revision	2026-07-03 06:37
Revised	2026-07-11 14:31
Publication Fee Transferred	2026-08-15 00:32
Second Decision by Editor	2026-10-29 07:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-29 10:23
Articles in Press	2026-10-29 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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