Publication Name	World Journal of Hepatology
Manuscript ID	124666
DOI	10.4254/wjh.124666
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study
Manuscript Source	Unsolicited Manuscript
All Author List	Giuseppe Colucci, Sonia Stella, Andrea Castagnetti, Laura Di Rito, Martina Lucà, Giulia Tosetti, Roberta D’Ambrosio and Pietro Lampertico
Funding Agency and Grant Number
Corresponding Author	Giuseppe Colucci, Associate Research Scientist, MD, Research Assistant Professor, Division of Gastroenterology and Hepatology, IRCCS Fondazione Ca’ Granda Ospedale Maggiore Policlinico, via F. Sforza 28, Milan 20122, Italy. giuseppe.colucci@guest.unimi.it
Key Words	Microbiome; Cirrhosis; Portal hypertension; Dysbiosis; Biodiversity
Core Tip	The gut-liver axis is affected in cirrhosis with clinically significant portal hypertension and may contribute to disease progression and liver decompensation. In a group of patients recruited in a pilot study, we detected significant differences in the intestinal microbiota and mycobiota compared to healthy controls, including the presence of specific pathobionts. Dietary modifications and the supplementation of specific pre and probiotics may help preventing disease progression in patients with cirrhosis and clinically significant portal hypertension.
Citation	Colucci G, Stella S, Castagnetti A, Di Rito L, Lucà M, Tosetti G, D’Ambrosio R, Lampertico P. Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124666
PDF	124666-in-press.pdf

Received	2026-06-26 07:57
Peer-Review Started	2026-06-26 07:58
First Decision by Editorial Office Director
Return for Revision	2026-07-22 06:25
Revised	2026-08-01 14:41
Publication Fee Transferred
Second Decision by Editor	2026-09-20 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-20 10:47
Articles in Press	2026-09-20 10:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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