Publication Name	World Journal of Hepatology
Manuscript ID	124789
DOI	10.4254/wjh.124789
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatocellular carcinoma with obstructive jaundice: Biliary drainage and multimodal therapy
Manuscript Source	Invited Manuscript
All Author List	Pan Xiao, Ke-Xin Chen, Lian-Lu Jiang and Li Zhang
Funding Agency and Grant Number
Corresponding Author	Lian-Lu Jiang, Chief Physician, Researcher, Department of Hepatobiliary, Pancreatic and Splenic Surgery, First Affiliated Hospital of Hunan College of TCM (Hunan Province Directly Affiliated TCM Hospital), No. 50 Renmin Middle Road, Lusong District, Zhuzhou 412000, Hunan Province, China. jiexiu666@gmail.com
Key Words	Hepatocellular carcinoma; Obstructive jaundice; Bile duct tumor thrombus; Biliary drainage; Transarterial chemoembolization; Hepatic arterial infusion chemotherapy; Immunotherapy; Multidisciplinary management
Core Tip	Patients with hepatocellular carcinoma-related jaundice should first be evaluated for a mechanical obstructive component rather than assumed to have irreversible liver failure. Endoscopic or percutaneous drainage may relieve cholestasis and allow treatment reassessment, but response definitions vary and apparent survival advantages are vulnerable to selection bias. Transarterial chemoembolization has the largest direct post-drainage evidence base; hepatic arterial infusion chemotherapy, radiotherapy, systemic therapy, and transplantation are supported mainly by small retrospective studies, case reports, or extrapolation. Drainage modality and subsequent treatment should be individualized by a multidisciplinary team, with clinical trials preferred whenever feasible.
Citation	Xiao P, Chen KX; Jiang LL; Zhang L. Hepatocellular carcinoma with obstructive jaundice: Biliary drainage and multimodal therapy. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124789
PDF	124789-in-press.pdf

Received	2026-06-24 07:04
Peer-Review Started	2026-06-24 07:04
First Decision by Editorial Office Director
Return for Revision	2026-07-21 07:13
Revised	2026-07-23 08:16
Publication Fee Transferred
Second Decision by Editor	2026-08-12 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-14 10:12
Articles in Press	2026-08-14 10:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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