Publication Name	World Journal of Diabetes
Manuscript ID	124847
DOI	10.4239/wjd.124847
Country	China

Category	Cell Biology
Manuscript Type	Review
Article Title	Pathophysiological mechanisms and risk factors linking type 2 diabetes mellitus and sarcopenia: A narrative review
Manuscript Source	Invited Manuscript
All Author List	Xiu-Li Xie, Hai-Yan Cao, Zi-Tong Wang, Hao-Ran Chen, Li-Sui Zhou, Tao Qian and Zhong-Yu Han
Funding Agency and Grant Number
Corresponding Author	Zhong-Yu Han, Academic Fellow, School of Medicine, Southeast University, No. 2 Southeast University Road, Jiangning District, Nanjing 210009, Jiangsu Province, China. hzyczy1997@163.com
Key Words	Type 2 diabetes mellitus; Muscle loss; Sarcopenia; Risk factors; Resistance training
Core Tip	Type 2 diabetes mellitus significantly accelerates skeletal muscle decline and is an independent risk factor for sarcopenia, particularly in older adults. This review highlights key interconnected mechanisms – including insulin resistance, chronic inflammation, mitochondrial dysfunction, and altered protein metabolism – that drive muscle loss in type 2 diabetes mellitus. Given the high and often underrecognized prevalence of sarcopenia in diabetic populations, early screening and integrated management are essential. Multimodal strategies combining glycaemic control, resistance exercise, adequate nutrition, and muscle-protective pharmacotherapy may effectively mitigate functional decline and improve patient outcomes.
Citation	Xie XL, Cao HY, Wang ZT, Chen HR, Zhou LS, Qian T, Han ZY. Pathophysiological mechanisms and risk factors linking type 2 diabetes mellitus and sarcopenia: A narrative review. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.124847
PDF	124847-in-press.pdf

Received	2026-06-25 02:25
Peer-Review Started	2026-06-28 23:55
First Decision by Editorial Office Director
Return for Revision	2026-07-20 09:04
Revised	2026-07-30 09:03
Publication Fee Transferred
Second Decision by Editor	2026-08-18 00:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-09 10:27
Articles in Press	2026-09-09 10:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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