Publication Name	World Journal of Hepatology
Manuscript ID	124889
DOI	10.4254/wjh.124889
Country	Viet Nam

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Frailty in metabolic dysfunction-associated steatotic liver disease: A cardio-hepatic-geriatric perspective on the liver-muscle-heart axis
Manuscript Source	Invited Manuscript
All Author List	Thang Viet Luong, Hung Minh Vu, Kim Yen Nguyen, Phuoc Le Huu, Hung Tran Xuan, Hai Nguyen Ngoc Dang, Duong Hung Tran and Bich Ngoc Hoang Thi
Funding Agency and Grant Number
Corresponding Author	Duong Hung Tran, MD, Researcher, University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue 530000, Viet Nam. tran.hduong0210@gmail.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Frailty; Sarcopenia; Myosteatosis; Physical function; Cardiovascular dysfunction
Core Tip	Frailty adds a functional dimension to metabolic dysfunction-associated steatotic liver disease that is not captured by liver-centered assessment alone. Hepatic disease, skeletal muscle impairment, and cardiovascular dysfunction may jointly reduce physiological reserve, while functional status may not parallel liver disease severity. The liver-muscle-heart framework highlights the value of assessing muscle strength, physical performance, nutrition, and independence alongside conventional hepatic and cardiometabolic risk assessment.
Citation	Luong TV, Vu HM, Nguyen KY, Le Huu P, Tran Xuan H, Dang HNN, Tran DH, Hoang Thi BN. Frailty in metabolic dysfunction-associated steatotic liver disease: A cardio-hepatic-geriatric perspective on the liver-muscle-heart axis. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124889
PDF	124889-in-press.pdf

Received	2026-06-26 06:15
Peer-Review Started	2026-06-26 06:15
First Decision by Editorial Office Director
Return for Revision	2026-07-17 10:28
Revised	2026-09-20 19:32
Publication Fee Transferred
Second Decision by Editor	2026-10-30 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-30 10:25
Articles in Press	2026-10-30 10:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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