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Articles in Press
10/10/2026 9:07:11 AM | Browse: 19 | Download: 0
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Shared genetic, epigenetic, and therapeutic landscapes of insomnia and psychiatric disorders
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Zhang, Ying Huang, Shu-Lei Huang, Hong-Ping Li, Yi-Ming Wang and Jun-Wen Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82260878, No.82560885 |
| Guizhou Provincial Clinical Medical Research Center Construction Project - Neurological Disease Research |
No. LCZX[2025]003 |
| Guizhou Provincial Science and Technology Innovation Leading Talent Workstation |
No.KXJZ[2025]047 |
| The “Xin Zhi Qian Yan” Leading Project of Guizhou Association for Science and Technology |
No. QKX2026-KC-YZ033 |
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| Corresponding Author |
Jun-Wen Wang, PhD, Department of Psychosomatic Medicine, The Second People’s Hospital of Guiyang, No. 547 Jinyang South Road, Guanshanhu District, Guiyang 550000, Guizhou, China. wjunw1206@163.com |
| Key Words |
Insomnia; Psychiatric disorders; Mendelian randomization; Multi-omics; Gene expression regulation |
| Core Tip |
This study integrates two-sample Mendelian randomization with tissue- and cell-type-specific expression and methylation quantitative trait loci to investigate shared genetic features between insomnia and ten psychiatric disorders. Genetically predicted insomnia was associated with bipolar disorder, major depressive disorder, and neuroticism after multiple-testing correction. Multi-omics analyses highlighted excitatory neurons and identified overlapping methylation–expression signals, including those involving MAP2K5 and CLP1. Integration with drug-target data further identified 14 candidate targets. These findings provide testable molecular hypotheses but require functional and clinical validation. |
| Citation |
Zhang J, Huang Y, Huang SL, Li HP, Wang YM, Wang JW. Shared genetic, epigenetic, and therapeutic landscapes of insomnia and psychiatric disorders. World J Psychiatry 2026; In press
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Received |
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2026-06-29 08:48 |
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Peer-Review Started |
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2026-06-29 08:48 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-09 07:49 |
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Revised |
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2026-07-28 02:36 |
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Publication Fee Transferred |
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2026-08-10 11:36 |
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Second Decision by Editor |
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2026-10-10 03:25 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-10 09:07 |
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Articles in Press |
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2026-10-10 09:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2220-3206 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
