Publication Name	World Journal of Gastroenterology
Manuscript ID	125044
DOI	10.3748/wjg.125044
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Lauric acid attenuates 14-day DDC-induced cholangiopathy in association with reduced NF-κB-CCL2 signaling and restored LRH-1-regulated gene expression
Manuscript Source	Unsolicited Manuscript
All Author List	Swati Ghosh, Michael W Devereaux, Colin C Anderson, David J Orlicky and Ronald J Sokol
Funding Agency and Grant Number	Funding Agency Grant Number the Childhood Liver Disease Research Network (NIDDK, NIH) U01DK062453
Corresponding Author	Swati Ghosh, Principal Investigator, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado Anschutz School of Medicine, 12700 East 19th Avenue, Aurora, CO 80045, United States. swati.ghosh@cuanschtz.edu
Key Words	Lauric acid; Liver receptor homolog-1; Cholestasis; Hepatocyte; Macrophage; Nuclear factor-kappa B; 3,5-diethoxycarbonyl-1,4-dihydrocollidine
Core Tip	Lauric acid (LA), a dietary medium-chain fatty acid, was studied in a 14-day 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced mouse model. Concurrent 5% LA supplementation attenuated biochemical cholestasis, hepatocellular injury, ductular reaction, collagen deposition, oxidative stress, senescence, and cell-death markers. These effects were associated with reduced nuclear factor-kappa B - C-C motif chemokine ligand 2 signaling, restored liver receptor homolog-1-regulated gene expression, and increased hepatic dilauroylphosphatidylcholine abundance. This study demonstrates a decrease in the development of liver injury but was not designed to demonstrate reversal of established liver injury. Further investigation will be needed to determine if liver receptor homolog-1 or dilauroylphosphatidylcholine is required for LA protection in this model.
Citation	Ghosh S, Devereaux MW, Anderson CC, Orlicky DJ, Sokol RJ. Lauric acid attenuates 14-day DDC-induced cholangiopathy in association with reduced NF-κB-CCL2 signaling and restored LRH-1-regulated gene expression. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125044
PDF	125044-in-press.pdf

Received	2026-06-30 02:43
Peer-Review Started	2026-06-30 02:43
First Decision by Editorial Office Director
Return for Revision	2026-07-17 02:34
Revised	2026-07-30 16:40
Publication Fee Transferred	2026-08-21 15:31
Second Decision by Editor	2026-09-29 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-29 09:44
Articles in Press	2026-09-29 09:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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