Publication Name	World Journal of Nephrology
Manuscript ID	125087
DOI	10.5527/wjn.125087
Country	Australia

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	B cells as targets for managing glomerular diseases: A review of contemporary and novel therapies
Manuscript Source	Invited Manuscript
All Author List	Samuel S Y Wang, Mingyi Suo, Dennis Jun Wei Ooi, Ting Hui Woon, Jie Lin, Xun Lyu and Muhammad Masoom Javaid
Funding Agency and Grant Number
Corresponding Author	Muhammad Masoom Javaid, Department of Medicine, South West Healthcare, 25 Ryot Street, Warrnambool 3280, Victoria, Australia. mmjavaid@doctors.org.uk
Key Words	B lymphocytes; B cells; Autoimmune; Glomerular diseases; Glomerulonephritis; Immunosuppression
Core Tip	B-cell-directed therapies have significantly improved the management of immune-mediated glomerular diseases. Although rituximab is the most commonly used agent, its effectiveness can be constrained by incomplete B-cell depletion, disease relapse, anti-drug antibody development, and the persistence of CD20-negative plasmablasts and plasma cells. Novel therapeutic approaches targeting next-generation CD20, CD38, B cell activating factor/B-lymphocyte stimulator, a proliferation-inducing ligand, CD40/CD40 L, proteasome-dependent plasma-cell survival, CD19, and B-cell maturation antigen have the potential to broaden treatment options for patients with relapsing or refractory disease. However, geographic differences in agent availability and financial constraints may limit their use in certain countries.
Citation	Wang SSY, Suo M, Ooi DJW, Woon TH, Lin J, Lyu X, Javaid MM. B cells as targets for managing glomerular diseases: A review of contemporary and novel therapies. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.125087
PDF	125087-in-press.pdf

Received	2026-07-01 06:22
Peer-Review Started	2026-07-01 06:22
First Decision by Editorial Office Director
Return for Revision	2026-07-23 03:34
Revised	2026-09-13 04:17
Publication Fee Transferred
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:28
Articles in Press	2026-11-02 03:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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