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Articles in Press
10/16/2026 9:16:43 AM | Browse: 17 | Download: 1
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Han Zheng, Yang-Yang Wang, Shu-Chang Wang, Chao-Jie Wang, Yan-Ying Shen, Jian-Zhi Cui, Shi-Meng Liu, Ye-Hao Zhang, Xue-Qin Zeng and En-Hao Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Shanghai Municipality |
23ZR1439400 |
| the National Natural Science Foundation of China |
82103348 |
| the Fundamental Research Funds for the Central Universities |
YG2023QNA10 |
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| Corresponding Author |
En-Hao Zhao, Chief Physician, MD, PhD, Professor, Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China. zhaoenhao@renji.com |
| Key Words |
Gastric adenocarcinoma; Poorly cohesive carcinoma; Signet ring cell carcinoma; Pathological classification; Prognosis; Retrospective cohort study |
| Core Tip |
This single-center retrospective cohort study evaluated poorly cohesive gastric carcinoma and its subtypes, defined by the proportions of signet ring cell (SRC) and poorly cohesive carcinoma-not otherwise specified (PCC-NOS) components, and identified distinct clinicopathological and immunohistochemical profiles. Although the SRC-dominant group was associated with superior overall survival, this prognostic advantage disappeared after propensity score matching, whereas the PCC-NOS-dominant group was potentially associated with microsatellite instability and programmed death protein ligand 1 expression. These findings emphasize the need for further investigation and comprehensive evaluation of poorly cohesive carcinoma and its subtypes. |
| Citation |
Zheng YH, Wang YY, Wang SC, Wang CJ, Shen YY, Cui JZ, Liu SM, Zhang YH, Zeng XQ, Zhao EH. Clinicopathological, immunohistochemical, and overall-survival associations of poorly cohesive gastric carcinoma stratified by signet ring cell percentage. World J Clin Oncol 2026; In press
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| PDF |
125097-in-press.pdf
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Received |
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2026-07-01 08:58 |
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Peer-Review Started |
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2026-07-01 08:58 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-03 05:49 |
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Revised |
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2026-08-24 13:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-15 03:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-16 09:16 |
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Articles in Press |
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2026-10-16 09:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
