Publication Name	World Journal of Clinical Oncology
Manuscript ID	125117
DOI	10.5306/wjco.125117
Country	China

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Development and internal validation of a disease-free survival model after radical resection of pathological T4 colorectal adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Qing-Yuan Zeng, Xue-Lian Wu, Qian-Ru Hang, Rong-Peng Chen and Guo-Qiang Wang
Funding Agency and Grant Number
Corresponding Author	Guo-Qiang Wang, MD, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgang East Road, Haizhu District, Guangzhou 510260, Guangdong Province, China. wgqjyh@126.com
Key Words	Colorectal neoplasms; Disease-free survival; Prognostic model; Pathological T4; Nomogram; Internal validation
Core Tip	This single-center retrospective cohort study developed and internally validated a postoperative disease-free survival model for 440 patients with radically resected pathological T4 colorectal adenocarcinoma. Seven routinely available clinical and pathological variables were retained. The conditional optimism-corrected concordance index was 0.652, and the model showed higher discrimination than a TNM-only comparator within the development cohort. Apparent calibration was generally close, and decision-curve analysis suggested potential net benefit. The complete prediction equation and nomogram are provided. External validation and clinical-impact assessment are required before clinical use.
Citation	Zeng QY, Wu XL, Hang QR, Chen RP, Wang GQ. Development and internal validation of a disease-free survival model after radical resection of pathological T4 colorectal adenocarcinoma. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.125117
PDF	125117-in-press.pdf

Received	2026-07-01 08:57
Peer-Review Started	2026-07-01 08:58
First Decision by Editorial Office Director
Return for Revision	2026-08-08 01:20
Revised	2026-08-19 07:10
Publication Fee Transferred
Second Decision by Editor	2026-10-22 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-22 09:07
Articles in Press	2026-10-22 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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