Publication Name	World Journal of Cardiology
Manuscript ID	125199
DOI	10.4330/wjc.125199
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Cardiac xenotransplantation: From imagination to achievable practice
Manuscript Source	Invited Manuscript
All Author List	Cai-Hong Wan, Bo-Yi Zhou and Yu-Long Guan
Funding Agency and Grant Number
Corresponding Author	Yu-Long Guan, MD, Professor, Department of Extracorporeal Circulation, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100037 Beijing, China, No 167, Beilishi Road, Xicheng District, Beijing 100037, China, Beijing 100037, China. guanyulong2014@163.com
Key Words	Heart failure; Heart transplantation; Xenotransplantation; Genetic engineering; Pig
Core Tip	Cardiac xenotransplantation has advanced from the failed animal-heart attempts of 1964-1984 to two landmark first-in-human compassionate-use transplants of 10-gene-edited pig hearts in 2022 and 2023. Although both recipients died within 40-60 days, these proof-of-concept cases defined the key remaining barriers-antibody-mediated injury, porcine viral reactivation, and diastolic dysfunction-that must be resolved before gene-edited pig hearts may be explored in the further clinical trials and act as one of reliable and effective means for the treatment of end-stage heart failure.
Citation	Wan CH, Zhou BY, Guan YL. Cardiac xenotransplantation: From imagination to achievable practice. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.125199
PDF	125199-in-press.pdf

Received	2026-07-02 05:53
Peer-Review Started	2026-07-02 05:53
First Decision by Editorial Office Director
Return for Revision	2026-07-17 06:06
Revised	2026-07-30 07:26
Publication Fee Transferred
Second Decision by Editor	2026-08-20 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-20 09:16
Articles in Press	2026-08-20 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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