Publication Name	World Journal of Immunology
Manuscript ID	125225
DOI	10.5411/wji.125225
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Metabolic inflammation in metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Chun-Ye Zhang and Ming Yang
Funding Agency and Grant Number
Corresponding Author	Ming Yang, Assistant Professor, PhD, Department of Surgery, School of Medicine, University of Connecticut, 263 Farmington Avenue, Farmington, CT 06030, United States. minyang@uchc.edu
Key Words	Metainflammation; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction and alcohol-associated liver disease; Lipid metabolism; Immunity; Liver fibrosis; Clinical trials
Core Tip	Metainflammation contributes to the pathogenesis of numerous metabolic disorders and chronic diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-associated liver disease (MetALD). It promotes hepatic lipid accumulation, inflammation, fibrosis, and cell death, thereby accelerating the progression of MASLD or MetALD to cirrhosis and liver cancer. Therapeutic strategies targeting metainflammation, including gut microbiome-directed therapies, dietary modulation, antioxidant interventions, and modulation of lipid metabolism, represent promising therapies for metabolic liver diseases.
Citation	Zhang CY, Yang M. Metabolic inflammation in metabolic dysfunction-associated steatotic liver disease. World J Immunol 2026; In press DOI: https://doi.org/10.5411/wji.125225
PDF	125225-in-press.pdf

Received	2026-07-02 02:52
Peer-Review Started	2026-07-02 02:53
First Decision by Editorial Office Director
Return for Revision	2026-07-20 07:40
Revised	2026-08-02 03:58
Publication Fee Transferred
Second Decision by Editor	2026-10-16 03:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-16 09:26
Articles in Press	2026-10-16 09:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2824 (online)
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