Publication Name	World Journal of Diabetes
Manuscript ID	125253
DOI	10.4239/wjd.125253
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Advanced liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Yu Yang, Ji-Hong Dong, Xin-Xia Chang, Hong-Mei Yan, Xiao-Peng Zhu, Xiao-Yang Sun, Yu-Ying Zhang, Qi-Ling Liu, Miao Zhang, Chen-Min Fan, Bing-Er Xu, Shu-Qi Li, Xin Gao, Ming-Feng Xia and Hua Bian
Funding Agency and Grant Number	Funding Agency Grant Number National Science and Technology Major Project 2023ZD0508703 National Natural Science Foundation of China 82370870 National Natural Science Foundation of China 82571003 Science and Technology Commission of Shanghai Municipality 22Y31900302 Shanghai Municipal Health Commission 202240295 Fudan University Affiliated Zhongshan Hospital First Batch of Specialized Disease Cohort Biobank Construction Project 2025ZSSWYBK11
Corresponding Author	Hua Bian, Chief Physician, MD, PhD, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Shanghai 200032, China. zhongshan_bh@126.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Diabetic peripheral neuropathy; Distal symmetric polyneuropathy; Liver fibrosis; Risk; Hepatic-nerve axis
Core Tip	This study identifies a subtype-specific association between liver fibrosis and diabetic peripheral neuropathy, revealing that advanced fibrosis is an independent predictor exclusively for distal symmetric polyneuropathy. Utilizing a large-scale inpatient cohort (n = 3066) and a biopsy-confirmed validation cohort (n = 132), the findings establish a robust “hepatic-nerve axis” in patients with type 2 diabetes.
Citation	Yang XY, Dong JH, Chang XX, Yan HM, Zhu XP, Sun XY, Zhang YY, Liu QL, Zhang M, Fan CM, Xu BE, Li SQ, Gao X, Xia MF, Bian H. Advanced liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.125253
PDF	125253-in-press.pdf

Received	2026-07-03 01:38
Peer-Review Started	2026-07-05 23:59
First Decision by Editorial Office Director
Return for Revision	2026-07-13 08:37
Revised	2026-07-28 17:10
Publication Fee Transferred	2026-08-31 15:57
Second Decision by Editor	2026-10-10 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:08
Articles in Press	2026-10-28 10:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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