Publication Name	World Journal of Psychiatry
Manuscript ID	125264
DOI	10.5498/wjp.125264
Country	China

Category	Anthropology
Manuscript Type	Observational Study
Article Title	Symptom network and directed acyclic graph of traditional Chinese medicine body constitution and depression: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Liang-Liang Huang, Zhi-Shan Wang, Hao-Ran Liu, Yu-Xin Tang, Zhi-Ming Luo, Qiao Lin and Huang-Wei Lei
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China for Young Scientists No. 82505379 National TCM Inheritance and Innovation Team for Traditional Chinese Diagnostics and Health-State Identification No. ZYYCXTD-C-202408 High-level Talent Project of Fujian University of Traditional Chinese Medicine No. X2020008-Talent
Corresponding Author	Huang-Wei Lei, Associate Professor, PhD, College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, No. 1 Qiuyang Road, Fuzhou 350122, Fujian Province, China. 2020039@fjtcm.edu.cn
Key Words	Depression; Traditional Chinese medicine body constitution; Network analysis; Directed acyclic graph; Psychosomatic symptoms; Individualized intervention
Core Tip	This study applied symptom network analysis and directed acyclic graph methods to examine the interaction network between body constitution and depression, offering a novel interdisciplinary perspective on mental disorders. Qi-deficiency and Qi-stagnation constitutions may be the predisposing traits contributing to the sustained depressive network. “Depressed, sad, and blue” represented a primary central node; “nervousness and anxiety” exhibited the highest expected influence and tended to form potential directional associations with somatic symptoms; “sleep disorder” acted as a key bridging node; and “adequate vitality” appeared to confer a protective effect. Individualized constitutional interventions may help modulate the pathological network architecture of depression.
Citation	Huang LL, Wang ZS, Liu HR, Tang YX, Luo ZM, Lin Q, Lei HW. Symptom network and directed acyclic graph of traditional Chinese medicine body constitution and depression: A cross-sectional study. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.125264
PDF	125264-in-press.pdf

Received	2026-07-06 08:12
Peer-Review Started	2026-07-06 08:12
First Decision by Editorial Office Director
Return for Revision	2026-07-21 06:08
Revised	2026-08-04 06:21
Publication Fee Transferred	2026-08-22 07:34
Second Decision by Editor	2026-09-16 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-16 09:42
Articles in Press	2026-09-16 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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