Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	125273
DOI	10.4251/wjgo.125273
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Inflammation-driven carcinogenesis in ulcerative colitis: Molecular and immunological pathways
Manuscript Source	Invited Manuscript
All Author List	Paulina Delgado-Gonzalez, Adriana G Quiroz-Reyes, Mario A Simental-Mendía, Veronica L Loaiza-Gutiérrez and Elsa N Garza-Treviño
Funding Agency and Grant Number
Corresponding Author	Paulina Delgado-Gonzalez, Research Assistant Professor, Department of Biochemistry and Molecular Medicine, School of Medicine, Universidad Autonoma de Nuevo Leon, s/n, Monterrey 64460, Nuevo León, Mexico. paulina.delgadogn@uanl.edu.mx
Key Words	Ulcerative colitis; Colorectal cancer; Bowel dysbiosis; Chronic inflammation; Immune evasion; Oxidative stress
Core Tip	Chronic inflammation in ulcerative colitis disrupts immune balance and gut microbiota, leading to reactive oxygen species production and driving molecular changes that foster colorectal cancer like cell growth, anti-apoptosis. This article synthesizes immunological, inflammatory, and molecular mechanisms in ulcerative colitis-associated carcinogenesis highlights risk factors such dysbiosis, biomarker identification, genomic instability, immune evasion and therapeutic implications for cancer prevention, while outlining future research directions to improve diagnostics and treatment.
Citation	Delgado-Gonzalez P, Quiroz-Reyes AG, Simental-Mendía MA, Loaiza-Gutiérrez VL, Garza-Treviño EN. Inflammation-driven carcinogenesis in ulcerative colitis: Molecular and immunological pathways. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.125273
PDF	125273-in-press.pdf

Received	2026-07-03 03:24
Peer-Review Started	2026-07-03 03:24
First Decision by Editorial Office Director
Return for Revision	2026-07-08 02:00
Revised	2026-07-21 18:46
Publication Fee Transferred
Second Decision by Editor	2026-08-18 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-18 09:35
Articles in Press	2026-08-18 09:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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