Publication Name	World Journal of Gastroenterology
Manuscript ID	125390
DOI	10.3748/wjg.125390
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Efficacy and safety of disposable digital single-operator cholangioscopy: A noninferiority, multicenter, randomized, open-label, blinded endpoint trial
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan Xie, Jin-Yu Qiu, Min Ju, Shao-Ru Cai, Gao-Fei Kang, Pi Guo, Zhi-Liang Tang, Pei-Hua Cao and Ke-Bo Zhong
Funding Agency and Grant Number	Funding Agency Grant Number Guangdong S&T Program 2025B1111110001 National Key R&D Program of China 2022YFA1104900 2022 Artificial Liver Special Fund of the Beijing Liver and Gallbladder Health Public Welfare Foundation iGandanF-1082022-RGG053
Corresponding Author	Ke-Bo Zhong, MD, Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, No. 253 Gongye Middle Avenue, Haizhu District, Guangzhou 510280, Guangdong Province, China. zhongkb@smu.edu.cn
Key Words	Digital single-operator cholangioscopy; Fiberoptic single-operator cholangioscopy; Randomized controlled trial; Noninferiority trial; Comparative study
Core Tip	This randomized study compared digital cholangioscopy with fiberoptic cholangioscopy, from the perspective of clinical diagnostic requirements. The results revealed that digital cholangioscopy was significantly superior to fiberoptic cholangioscopy in terms of image quality, smoothness, sealability and flexibility, although the image quality compliance rates for clinical diagnostic requirements were comparable between the procedures. Additionally, the accessory could cooperate better with the instrument channel to complete the digital cholangioscopy procedure. Digital cholangioscopy represents a growing trend in minimally invasive biliary surgery.
Citation	Xie Y, Qiu JY, Ju M, Cai SR, Kang GF, Guo P, Tang ZL, Cao PH, Zhong KB. Efficacy and safety of disposable digital single-operator cholangioscopy: A noninferiority, multicenter, randomized, open-label, blinded endpoint trial. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125390
PDF	125390-in-press.pdf

Received	2026-07-06 03:19
Peer-Review Started	2026-07-06 03:19
First Decision by Editorial Office Director
Return for Revision	2026-07-23 07:13
Revised	2026-08-03 11:36
Publication Fee Transferred	2026-08-23 05:30
Second Decision by Editor	2026-09-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-09 10:31
Articles in Press	2026-09-09 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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