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Articles in Press
10/8/2026 9:24:29 AM | Browse: 22 | Download: 3
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Human umbilical cord blood-derived mesenchymal stem cell therapy in experimental spinal cord injury: A systematic review and meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Qiong Liao, Rui-Xia Liang, Zhu-Xiao Ren, Ye-Yang Wang, Wei Wei and Yong-Sheng Li |
| Funding Agency and Grant Number |
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| Corresponding Author |
Yong-Sheng Li, Manager, Laboratory Center, Guangdong Cord Blood Bank, No. 1 Nan Yun Fourth Road, Science City, Guangzhou 510663, Guangdong Province, China. life9999@yeah.net |
| Key Words |
Spinal cord injury; Stem cells; Umbilical cord blood; Mesenchymal stem cells; Meta-analysis; Preclinical research |
| Core Tip |
This systematic review and meta-analysis of six preclinical studies demonstrates that human umbilical cord blood-derived mesenchymal stem cell transplantation significantly improves functional recovery in experimental spinal cord injury, with a large effect size (standardized mean difference = 2.35). The certainty of evidence is low due to substantial heterogeneity and methodological limitations. A hypothesis-generating observation suggests that low doses (≤ 1 × 106 cells) may yield more consistent effects than higher doses, questioning the assumption of a simple linear dose-efficacy relationship. These findings provide an initial quantitative reference for future translational research. |
| Citation |
Liao LQ, Liang RX, Ren ZX, Wang YY, Wei W, Li YS. Human umbilical cord blood-derived mesenchymal stem cell therapy in experimental spinal cord injury: A systematic review and meta-analysis. World J Stem Cells 2026; In press
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| PDF |
125423-in-press.pdf
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Received |
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2026-07-07 07:08 |
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Peer-Review Started |
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2026-07-07 07:08 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-22 03:22 |
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Revised |
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2026-08-04 08:28 |
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Publication Fee Transferred |
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2026-09-04 06:35 |
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Second Decision by Editor |
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2026-09-22 02:16 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:24 |
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Articles in Press |
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2026-10-08 09:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
