Publication Name	World Journal of Cardiology
Manuscript ID	125519
DOI	10.4330/wjc.125519
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Maladaptive lipid partitioning in obesity-related heart failure with preserved ejection fraction: From depot dysfunction to metabolic phenotyping
Manuscript Source	Invited Manuscript
All Author List	Si-Shang Qin, Zi-Min Wu, Bao-Shi Zheng and Cheng Luo
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Guangxi 2025GXNSFAA069056 the National Natural Science Foundation of China 82360066 the Guangxi Key Research and Development Program Project guikeAB24010153
Corresponding Author	Cheng Luo, Assistant Professor, MD, Postdoc, Department of Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. drluocheng@163.com
Key Words	Heart failure with preserved ejection fraction; Obesity; Lipid partitioning; Epicardial adipose tissue; Metabolic inflexibility; Body composition
Core Tip	Obesity-related heart failure with preserved ejection fraction cannot be adequately characterized by body mass alone. This minireview focuses on the less frequently explored consequences of failed lipid storage: Depot-specific lipid rerouting across visceral, hepatic, skeletal muscle, epicardial/perivascular, and myocardial compartments, together with impaired myocardial substrate flexibility. We distinguish human associations from mechanistic evidence and propose adiposity-aware phenotyping as a research framework rather than a validated treatment algorithm. Recent cardiometabolic trials illustrate how complementary components of this phenotype may be therapeutically modifiable.
Citation	Qin SS, Wu ZM, Zheng BS, Luo C. Maladaptive lipid partitioning in obesity-related heart failure with preserved ejection fraction: From depot dysfunction to metabolic phenotyping. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.125519
PDF	125519-in-press.pdf

Received	2026-07-09 05:52
Peer-Review Started	2026-07-09 05:52
First Decision by Editorial Office Director
Return for Revision	2026-08-18 01:39
Revised	2026-09-09 16:54
Publication Fee Transferred
Second Decision by Editor	2026-10-13 06:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-13 09:51
Articles in Press	2026-10-13 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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