Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	125545
DOI	10.4240/wjgs.125545
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: From hemostasis to healing – rethinking the therapeutic paradigm for chronic radiation proctitis
Manuscript Source	Unsolicited Manuscript
All Author List	Sai-Han Zhang, Yu-Bo Wang and Bing Chang
Funding Agency and Grant Number
Corresponding Author	Bing Chang, Chief Physician, MD, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cb000216@163.com
Key Words	Chronic radiation proctitis; Microbiota transplantation; Mucosal healing; Thalidomide; Combination therapy
Core Tip	Thalidomide can effectively reduce bleeding in patients with chronic radiation proctitis, but improvement in mucosal structure appears less pronounced. Microbiota-based therapy, including fecal microbiota transplantation and washed microbiota transplantation, may complement thalidomide by restoring the intestinal microbial ecosystem and promoting mucosal recovery. Integrating haemostatic treatment with microbiota-based therapy may shift the therapeutic goal for chronic radiation proctitis from bleeding control toward mucosal healing.
Citation	Zhang SH, Wang YB, Chang B. Letter to the Editor: From hemostasis to healing – rethinking the therapeutic paradigm for chronic radiation proctitis. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.125545
PDF	125545-in-press.pdf

Received	2026-07-10 08:15
Peer-Review Started	2026-07-10 08:15
First Decision by Editorial Office Director
Return for Revision	2026-08-07 01:08
Revised	2026-08-20 15:58
Publication Fee Transferred
Second Decision by Editor	2026-09-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-10 10:08
Articles in Press	2026-09-10 10:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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