Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	125564
DOI	10.4253/wjge.125564
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Real-world clinical outcomes, prognostic factors, and safety profile of upadacitinib in patients with inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Vassiliki Kitsou, Georgios Kokkotis, Panagiotis Avatziadis, Alexandros Ioannou, Spyridon Michopoulos, Evanthia Zampeli and Giorgos Bamias
Funding Agency and Grant Number
Corresponding Author	Giorgos Bamias, MD, PhD, Professor, GI Unit, 3rd Academic Department of Internal Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Mesogeion Avenue 152, Athens 11527, Attikí, Greece. gbamias@gmail.com
Key Words	Upadacitinib; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Treatment; Drug sustainability; Efficacy
Core Tip	Our real-world study demonstrates that upadacitinib is an effective and well-tolerated treatment for patients with advanced therapy-refractory inflammatory bowel disease. Over a median follow-up of 66 weeks, upadacitinib showed high treatment persistence and clinical remission rates, particularly in patients with ulcerative colitis. Moreover, our study identifies baseline predictors for treatment discontinuation or intensification of upadacitinib in patients with ulcerative colitis, as well as predictors of endoscopic remission in both ulcerative colitis and Crohn’s disease, thus, providing insights into personalized management of patients.
Citation	Kitsou V, Kokkotis G, Avatziadis P, Ioannou A, Michopoulos S, Zampeli E, Bamias G. Real-world clinical outcomes, prognostic factors, and safety profile of upadacitinib in patients with inflammatory bowel disease. World J Gastrointest Endosc 2026; In press DOI: https://doi.org/10.4253/wjge.125564
PDF	125564-in-press.pdf

Received	2026-07-13 09:24
Peer-Review Started	2026-07-13 09:24
First Decision by Editorial Office Director
Return for Revision	2026-07-30 08:10
Revised	2026-08-13 11:56
Publication Fee Transferred
Second Decision by Editor	2026-10-09 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-09 09:21
Articles in Press	2026-10-09 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com