Publication Name	World Journal of Diabetes
Manuscript ID	125608
DOI	10.4239/wjd.125608
Country	Türkiye

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Once-weekly basal insulin analogs in type 2 diabetes: Pharmacological rationale, clinical evidence, and practical considerations for implementation
Manuscript Source	Unsolicited Manuscript
All Author List	Melike Yakut
Funding Agency and Grant Number
Corresponding Author	Melike Yakut, Department of Internal Medicine, Eskisehir Cifteler State Hospital, No. 2 İbrahim Dede Caddesi, Eskisehir 26700, Türkiye. melikeyakut95@gmail.com
Key Words	Insulin icodec; Insulin efsitora alfa; Type 2 diabetes; Once-weekly insulin; Basal insulin; Glycemic control; Hypoglycemia; Medication adherence; IcoSema; Clinical practice
Core Tip	Once-weekly basal insulin analogs reduce injection frequency from 365 to 52 per year. Insulin icodec, approved for type 2 diabetes in several jurisdictions including the European Union, Canada, and the United States, achieved superiority over daily comparators in insulin-naïve patients across the ONWARDS program. In QWINT-1, insulin efsitora alfa showed that a simplified fixed-step weekly regimen can match titrated daily insulin. Both agents increase hypoglycemia risk in type 1 diabetes. No head-to-head comparison exists. Implementation requires modified titration intervals, loading-dose awareness, and proactive sick-day planning.
Citation	Yakut M. Once-weekly basal insulin analogs in type 2 diabetes: Pharmacological rationale, clinical evidence, and practical considerations for implementation. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.125608
PDF	125608-in-press.pdf

Received	2026-07-14 02:52
Peer-Review Started	2026-07-16 09:58
First Decision by Editorial Office Director
Return for Revision	2026-07-30 01:53
Revised	2026-08-25 22:49
Publication Fee Transferred	2026-10-04 18:49
Second Decision by Editor	2026-10-23 00:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:20
Articles in Press	2026-11-02 03:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com