Publication Name	World Journal of Gastroenterology
Manuscript ID	125628
DOI	10.3748/wjg.125628
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Cohort Study
Article Title	Prognostic characteristics and exploratory prediction nomogram for rectal cancer patients with ypT0N+ status after neoadjuvant chemoradiotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Lun He, Xiao-Jie Wang, Can-Feng Cai, Zhi-Hao He, Xun-Lin Zhang, Tong-Tong Zhang, Zhi-Long Yuan, Ying Huang, Pan Chi and Bing Zeng
Funding Agency and Grant Number
Corresponding Author	Bing Zeng, PhD, Professor, Department of General Surgery, Hernia and Abdominal Wall Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, No. 26 Second Horizontal Road, Yan Village, Tianhe District, Guangzhou 510655, Guangdong Province, China. zengbing3@mail.sysu.edu.cn
Key Words	Rectal neoplasms; Neoadjuvant chemoradiotherapy; Primary tumor complete response; ypT0N+; Nomogram; Retrospective studies; Lymph node metastasis
Core Tip	Rectal cancer patients with ypT0N+ status after neoadjuvant chemoradiotherapy demonstrate poor long-term prognosis, exhibiting overall survival comparable to ypT1-2N1 disease and disease-free survival similar to ypT3N0 disease. While our nomogram combining extramural venous invasion and tumor distance from the anal verge provides a novel tool for estimating occult nodal risk, cautious external validation is essential before integrating it into organ preservation decision-making.
Citation	He TL, Wang XJ, Cai CF, He ZH, Zhang XL, Zhang TT, Yuan ZL, Huang Y, Chi P, Zeng B. Prognostic characteristics and exploratory prediction nomogram for rectal cancer patients with ypT0N+ status after neoadjuvant chemoradiotherapy. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125628
PDF	125628-in-press.pdf

Received	2026-07-13 06:46
Peer-Review Started	2026-07-13 06:46
First Decision by Editorial Office Director
Return for Revision	2026-08-03 06:03
Revised	2026-08-11 13:23
Publication Fee Transferred	2026-09-23 04:55
Second Decision by Editor	2026-11-11 06:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-11 10:08
Articles in Press	2026-11-11 10:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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