Publication Name	Artificial Intelligence in Gastrointestinal Endoscopy
Manuscript ID	125741
DOI	10.37126/aige.125741
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Sessile serrated lesions, interval cancer, and the unresolved limits of artificial intelligence-assisted colonoscopy
Manuscript Source	Unsolicited Manuscript
All Author List	Ahmed Salman and Mohamed AbdAlla Salman
Funding Agency and Grant Number
Corresponding Author	Ahmed Salman, FRACP, FRCP, Department of Internal Medicine, Kasr Alainy School of Medicine, Cairo University, 1 Al-Saray Street, Al-Manial, Cairo 11562, Egypt. awea844@gmail.com
Key Words	Artificial intelligence; Computer-aided detection; Colonoscopy; Sessile serrated lesion; Post-colonoscopy colorectal cancer; Deskilling
Core Tip	Computer-aided detection raises adenoma detection by about a fifth, but pooled randomized data have not established a benefit for sessile serrated lesions (risk ratio 1.10, 95% confidence interval: 0.93-1.30). Serrated detection was assessed only as an underpowered secondary endpoint, so a worthwhile effect remains possible. Water exchange and longer withdrawal have shown serrated signals in separate studies, but no adequately powered head-to-head trial with a serrated primary endpoint has established comparative effectiveness. Evidence of reduced unassisted vigilance is limited and observational. Serrated-specific trials and monitoring are needed before any effect on interval cancer can be inferred.
Citation	Salman A, Salman MA. Sessile serrated lesions, interval cancer, and the unresolved limits of artificial intelligence-assisted colonoscopy. Artif Intell Gastrointest Endosc 2026; In press DOI: https://doi.org/10.37126/aige.125741
PDF	125741-in-press.pdf

Received	2026-07-15 06:29
Peer-Review Started	2026-07-15 06:30
First Decision by Editorial Office Director
Return for Revision	2026-08-07 03:13
Revised	2026-08-15 11:36
Publication Fee Transferred
Second Decision by Editor	2026-09-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-09 10:31
Articles in Press	2026-09-09 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2689-7164 (online)
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