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Articles in Press
10/28/2026 10:23:08 AM | Browse: 27 | Download: 6
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Arabinoxylan and xylo-oligosaccharides regulate gastric microbiota and attenuate gastric carcinogenesis in A4gnt-knockout mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Li Li, Rui Shi, Yi-Xuan Wang, Zhi-Peng Li, Shu-Zhen Liang, Li-Li Wang and Quan-Jiang Dong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
No. 31870777 |
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| Corresponding Author |
Quan-Jiang Dong, PhD, Central Laboratories and Department of Gastroenterology, Qingdao Municipal Hospital, No. 5 Donghai Middle Road, Shinan District, Qingdao 266071, Shandong Province, China. jiangacer@126.com |
| Key Words |
Gastric cancer; Gastric microbiota; Arabinoxylan; Xylo-oligosaccharides; A4gnt-knockout mice |
| Core Tip |
In this study, we investigated the effects of arabinoxylan (AX) and xylo-oligosaccharides on gastric microbiota composition and lesion progression in A4gnt-knockout mice. Our results demonstrated that AX completely inhibited intramucosal tumorigenesis and ameliorated pathological gastric damage in A4gnt-knockout mice. Furthermore, AX substantially normalized the dysregulated diversity, structural configuration, and metabolic functions of the gastric microbiota, exhibiting superior efficacy compared with xylo-oligosaccharides. At the microbial level, AX-induced remodeling of the gastric microbiota may contribute to its protective effects against gastric lesions. |
| Citation |
Li WL, Shi R, Wang YX, Li ZP, Liang SZ, Wang LL, Dong QJ. Arabinoxylan and xylo-oligosaccharides regulate gastric microbiota and attenuate gastric carcinogenesis in A4gnt-knockout mice. World J Gastrointest Oncol 2026; In press
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| PDF |
125746-in-press.pdf
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Received |
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2026-07-16 08:22 |
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Peer-Review Started |
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2026-07-16 08:23 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-21 14:33 |
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Revised |
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2026-09-03 09:13 |
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Publication Fee Transferred |
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2026-09-21 11:38 |
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Second Decision by Editor |
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2026-10-28 07:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-28 10:23 |
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Articles in Press |
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2026-10-28 10:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
