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Articles in Press
10/20/2026 9:48:33 AM | Browse: 21 | Download: 10
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Excessive mitochondrial fission in myocardial ischemia/reperfusion injury: Pathophysiological relevance and potential cardioprotective modulation by plant-derived interventions and electroacupuncture
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Li Sun, Xing-Yi Sun, Zi-Han Na, Yi-Jia Liu, Lin Li, Tian-Yu Cao, Xin-Ran Li, Ya-Dong Fan, Gui-Ping Hu and Shuo Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Shuo Wang, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, West District, Tuanbo New City, Jinghai District, Tianjin 301617, China. wssean1609@163.com |
| Key Words |
Myocardial ischemia/reperfusion injury; Mitochondrial fusion; Mitochondrial fission; Dynamin-related protein 1; Optic atrophy 1; Mitochondrial fragmentation; Cardioprotection; Plant-derived natural products; Electroacupuncture |
| Core Tip |
Excessive mitochondrial fission is not merely a morphological consequence of myocardial ischemia/reperfusion injury, but a potential amplifier of mitochondrial dysfunction and cardiomyocyte death. This review highlights the complementary contributions of dynamin-related protein 1-centered fission activation and impaired fusion-mediated network repair. It further emphasizes that broad mitochondrial protection should not be equated with direct modulation of the fusion-fission machinery. Plant-derived interventions and electroacupuncture show experimental promise, but mechanistic causality and translational relevance remain insufficiently established. |
| Citation |
Sun L, Sun XY, Na ZH, Liu YJ, Li L, Cao TY, Li XR, Fan YD, Hu GP, Wang S. Excessive mitochondrial fission in myocardial ischemia/reperfusion injury: Pathophysiological relevance and potential cardioprotective modulation by plant-derived interventions and electroacupuncture. World J Cardiol 2026; In press
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| PDF |
125900-in-press.pdf
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Received |
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2026-07-21 11:21 |
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Peer-Review Started |
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2026-07-21 11:21 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-20 06:04 |
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Revised |
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2026-09-09 18:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-10-19 06:06 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-20 09:48 |
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Articles in Press |
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2026-10-20 09:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
