Publication Name	World Journal of Gastroenterology
Manuscript ID	125914
DOI	10.3748/wjg.125914
Country	China

Category	Pathology
Manuscript Type	Retrospective Cohort Study
Article Title	Trophoblast cell-surface antigen 2 expression in digestive neuroendocrine carcinomas: Subtype-associated patterns, ancillary diagnostic value, and uncertain prognostic significance
Manuscript Source	Unsolicited Manuscript
All Author List	Ran Wang, Bin-Yan Wu, Li-Sha Yin, Xiu-Li Ma, Xin-Ya Zhao, Ya-Jie Hu, Qing-Xia Zhang, Yang-Nan Shi, Ming Lu and Yu Sun
Funding Agency and Grant Number	Funding Agency Grant Number Capital’s Funds for Health Improvement and Research No. 2024-2-1024 Science and Innovation Program of Peking University Cancer Hospital & Institute No. KC2511
Corresponding Author	Yu Sun, MD, PhD, Professor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Pathology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. sunyu_bch@163.com
Key Words	Trophoblast cell-surface antigen 2; Neuroendocrine carcinoma; Large-cell neuroendocrine carcinoma; Grade 3 neuroendocrine tumor; Immunohistochemistry; Digestive system; Prognosis
Core Tip	In this study, trophoblast cell-surface antigen 2 (TROP2) expression was examined in a relatively large cohort of digestive neuroendocrine carcinomas. High TROP2 expression showed a subtype-associated pattern. TROP2 also provided ancillary value in distinguishing large-cell neuroendocrine carcinoma from grade 3 neuroendocrine tumors. High TROP2 expression was also more common in tumors with fewer positive conventional neuroendocrine markers. It was associated with poorer overall survival in the multivariable model, and time-varying analyses suggested a progressively stronger adverse association over follow-up. However, continuous H-score was not associated with overall survival, and the survival threshold showed limited stability; therefore, the prognostic findings remain exploratory and require external validation.
Citation	Wang R, Wu BY, Yin LS, Ma XL, Zhao XY, Hu YJ, Zhang QX, Shi YN, Lu M, Sun Y. Trophoblast cell-surface antigen 2 expression in digestive neuroendocrine carcinomas: Subtype-associated patterns, ancillary diagnostic value, and uncertain prognostic significance. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.125914
PDF	125914-in-press.pdf

Received	2026-07-24 07:55
Peer-Review Started	2026-07-24 07:55
First Decision by Editorial Office Director
Return for Revision	2026-08-05 07:56
Revised	2026-08-17 13:48
Publication Fee Transferred	2026-09-17 08:23
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:43
Articles in Press	2026-11-04 10:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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