Publication Name	World Journal of Hepatology
Manuscript ID	125990
DOI	10.4254/wjh.125990
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Translational artificial intelligence in therapeutic-era metabolic dysfunction-associated steatohepatitis: The ACTION framework
Manuscript Source	Invited Manuscript
All Author List	Yu-Hang Liu, Si-Yan Li, Shi-Tian Zhang and Zi-Xuan Zhu
Funding Agency and Grant Number
Corresponding Author	Yu-Hang Liu, Doctorate Student, The Second Clinical College, Chongqing Medical University, Chongqing Medical university,Chongqing,China. Electronic address: 13990562909@163.com, Chongqing 400010, China. 13990562909@163.com
Key Words	Artificial intelligence; Metabolic dysfunction-associated steatohepatitis; Metabolic dysfunction-associated steatotic liver disease; Clinical actionability; Non-invasive tests; Digital pathology; Drug-development tool
Core Tip	Therapeutic advances have shifted the relevant question for artificial intelligence in metabolic dysfunction-associated steatohepatitis from disease detection to decision support. The ACTION framework links each output to an attached action, contextual calibration, threshold-specific benefit, workflow integration, human oversight, and non-discrimination with lifecycle monitoring. Evidence is most mature for human-reviewed digital pathology in specified clinical-trial workflows. Case finding, non-invasive enrichment, biopsy stewardship and response modelling still require prospective evidence that model-guided actions improve care, rather than discrimination alone.
Citation	Liu YH, Li SY, Zhang ST, Zhu ZX. Translational artificial intelligence in therapeutic-era metabolic dysfunction-associated steatohepatitis: The ACTION framework. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.125990
PDF	125990-in-press.pdf

Received	2026-07-22 07:41
Peer-Review Started	2026-07-22 07:42
First Decision by Editorial Office Director
Return for Revision	2026-07-28 06:12
Revised	2026-07-29 12:01
Publication Fee Transferred
Second Decision by Editor	2026-09-09 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-09 10:32
Articles in Press	2026-09-09 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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