Publication Name	World Journal of Experimental Medicine
Manuscript ID	126036
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Corneal nerve imaging in systemic neuropathy: A minireview of experimental and precision medicine applications
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Francesco Cappellani, Ehimare Enaholo and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Peripheral neuropathy; Corneal nerves; Small fiber neuropathy; Confocal microscopy; Precision medicine
Core Tip	Corneal confocal microscopy provides a fast, non-invasive quantitative assessment of corneal small-nerve morphology and has shown reproducible group-level abnormality in diabetic peripheral neuropathy and a few other systemic neuropathies. Nevertheless, population-based distinctions do not mean a reliable diagnosis in a single patient. Research shows that when it comes to diabetic neuropathy, the best studied condition, the variability in diagnostic performance can be attributed to the studied population, the reference standard employed, the sampling protocol used, the analysis chosen and the threshold selected. Also, there is considerable overlap and variation between those affected and not affected.
Citation	Capobianco M, Cappellani F, Enaholo E, Zeppieri M. Corneal nerve imaging in systemic neuropathy: A minireview of experimental and precision medicine applications. World J Exp Med 2026; In press

Received	2026-07-29 03:36
Peer-Review Started	2026-08-05 02:34
First Decision by Editorial Office Director
Return for Revision	2026-09-08 07:59
Revised	2026-09-11 12:14
Publication Fee Transferred
Second Decision by Editor	2026-09-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-17 09:20
Articles in Press	2026-09-17 09:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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